BDBM15238 4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine::C14316::SB218655::SB3

SMILES Nc1nccc(n1)-c1c(ncn1CC1CC1)-c1ccc(F)cc1

InChI Key InChIKey=DFEYXQGDDCDXJK-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 15238   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Texas At Dallas

LigandPNGBDBM15238(4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...)
Affinity DataIC50:  25nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 0.17 mM ATP/[gamma-32P] ATP. 32P incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Texas At Dallas

LigandPNGBDBM15238(4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human MAPK p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB

TargetMitogen-activated protein kinase 1(Rattus norvegicus (rat))
University Of Texas At Dallas

LigandPNGBDBM15238(4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...)
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 0.17 mM ATP/[gamma-32P] ATP. 32P incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed