BDBM15249 7-chloro-3-oxo-11,16-dioxa-2,4,19,21-tetraazatricyclo[15.3.1.0^{5,10}]henicosa-1(20),5(10),6,8,17(21),18-hexaene-18-carbonitrile::CHEMBL375097::macrocyclic inhibitor 5c

SMILES Clc1ccc2OCCCCOc3nc(NC(=O)Nc2c1)cnc3C#N

InChI Key InChIKey=VMPYQVMKFSUWQM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 15249   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15249(7-chloro-3-oxo-11,16-dioxa-2,4,19,21-tetraazatricy...)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15249(7-chloro-3-oxo-11,16-dioxa-2,4,19,21-tetraazatricy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15249(7-chloro-3-oxo-11,16-dioxa-2,4,19,21-tetraazatricy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Chk1 enzyme by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed