Found 157 hits for monomerid = 15581 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
Reactome pathway
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Patents
Similars
| Article PubMed
| n/a | n/a | 6.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyra... |
Bioorg Med Chem 18: 5063-70 (2010)
Article DOI: 10.1016/j.bmc.2010.05.070 BindingDB Entry DOI: 10.7270/Q22F7PD1 |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyra... |
Bioorg Med Chem 18: 5063-70 (2010)
Article DOI: 10.1016/j.bmc.2010.05.070 BindingDB Entry DOI: 10.7270/Q22F7PD1 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mississippi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A using kynuramine as substrate preincubated with compound for 15 mins measured after 20 mins by fluorometric ana... |
Bioorg Med Chem Lett 22: 4926-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.058 BindingDB Entry DOI: 10.7270/Q21Z45GF |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
Reactome pathway
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Similars
| Article PubMed
| n/a | n/a | 9.40E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandria University
Curated by ChEMBL
| Assay Description Inhibition of MAOB by spectrophotometry |
Eur J Med Chem 45: 4479-89 (2010)
Article DOI: 10.1016/j.ejmech.2010.07.008 BindingDB Entry DOI: 10.7270/Q21G0N86 |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandria University
Curated by ChEMBL
| Assay Description Inhibition of MAOA by spectrophotometry |
Eur J Med Chem 45: 4479-89 (2010)
Article DOI: 10.1016/j.ejmech.2010.07.008 BindingDB Entry DOI: 10.7270/Q21G0N86 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 0.00490 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Inhibition of human monoamine oxidase A |
Bioorg Med Chem 18: 7675-99 (2010)
Article DOI: 10.1016/j.bmc.2010.07.034 BindingDB Entry DOI: 10.7270/Q2DF6S69 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| DrugBank PDB Article PubMed
| n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
General Hospital of PLA
Curated by ChEMBL
| Assay Description Inhibition of MAO-A in Sprague-Dawley rat brain homogenate using kynuramine as substrate preincubated for 10 mins measured by fluorimetric assay |
Bioorg Med Chem Lett 22: 3343-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.090 BindingDB Entry DOI: 10.7270/Q2JW8FWM |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine Oxidase Type B (MAO-B)
(Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
General Hospital of PLA
Curated by ChEMBL
| Assay Description Inhibition of MAO-B in Sprague-Dawley rat brain homogenate using kynuramine as substrate preincubated for 10 mins measured by fluorimetric assay |
Bioorg Med Chem Lett 22: 3343-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.090 BindingDB Entry DOI: 10.7270/Q2JW8FWM |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells using p-tyramine as substrate incubated for 15 mins prior to substrate... |
Eur J Med Chem 58: 405-17 (2012)
Article DOI: 10.1016/j.ejmech.2012.10.032 BindingDB Entry DOI: 10.7270/Q20G3M75 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| Article PubMed
| n/a | n/a | 6.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells using p-tyramine as substrate incubated for 15 mins prior to substrate... |
Eur J Med Chem 58: 405-17 (2012)
Article DOI: 10.1016/j.ejmech.2012.10.032 BindingDB Entry DOI: 10.7270/Q20G3M75 |
More data for this Ligand-Target Pair | |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| Article PubMed
| n/a | n/a | 4.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-B using kynuramine as substrate measured after 30 mins by fluorescence assay |
Bioorg Med Chem 25: 714-726 (2017)
Article DOI: 10.1016/j.bmc.2016.11.048 BindingDB Entry DOI: 10.7270/Q21C1ZVW |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A using kynuramine as substrate measured after 30 mins by fluorescence assay |
Bioorg Med Chem 25: 714-726 (2017)
Article DOI: 10.1016/j.bmc.2016.11.048 BindingDB Entry DOI: 10.7270/Q21C1ZVW |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Okayama University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA using p-tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by horse... |
Eur J Med Chem 121: 864-879 (2016)
Article DOI: 10.1016/j.ejmech.2015.10.001 BindingDB Entry DOI: 10.7270/Q2B27X8T |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| Article PubMed
| n/a | n/a | 6.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Okayama University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOB using p-tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by horse... |
Eur J Med Chem 121: 864-879 (2016)
Article DOI: 10.1016/j.ejmech.2015.10.001 BindingDB Entry DOI: 10.7270/Q2B27X8T |
More data for this Ligand-Target Pair | |
Cholinesterases
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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Patents
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| Article PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Okayama University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant BuChE expressed in HEK293 cells using S-butyrylthiocholine iodide as substrate preincubated for 30 mins followed by s... |
Eur J Med Chem 121: 864-879 (2016)
Article DOI: 10.1016/j.ejmech.2015.10.001 BindingDB Entry DOI: 10.7270/Q2B27X8T |
More data for this Ligand-Target Pair | |
Cholinesterases
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
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Patents
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| Article PubMed
| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Okayama University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 30 mins followed by subst... |
Eur J Med Chem 121: 864-879 (2016)
Article DOI: 10.1016/j.ejmech.2015.10.001 BindingDB Entry DOI: 10.7270/Q2B27X8T |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected High 5 insect cells using kynuramine as substrate incubated for 30 mins by sp... |
Bioorg Med Chem 25: 1030-1041 (2017)
Article DOI: 10.1016/j.bmc.2016.12.013 BindingDB Entry DOI: 10.7270/Q2PR7XZS |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| Article PubMed
| n/a | n/a | 4.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-B expressed in baculovirus infected High 5 insect cells using kynuramine as substrate incubated for 30 mins by sp... |
Bioorg Med Chem 25: 1030-1041 (2017)
Article DOI: 10.1016/j.bmc.2016.12.013 BindingDB Entry DOI: 10.7270/Q2PR7XZS |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human recombinant microsomal MAO-A expressed in baculovirus-infected insect cells using p-tyramine as substrate preincubated for 15 min... |
Bioorg Med Chem 25: 633-645 (2017)
Article DOI: 10.1016/j.bmc.2016.11.032 BindingDB Entry DOI: 10.7270/Q2HH6N2G |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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Patents
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| Article PubMed
| n/a | n/a | 1.36E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human recombinant microsomal MAO-B expressed in baculovirus-infected insect cells using p-tyramine as substrate preincubated for 15 min... |
Bioorg Med Chem 25: 633-645 (2017)
Article DOI: 10.1016/j.bmc.2016.11.032 BindingDB Entry DOI: 10.7270/Q2HH6N2G |
More data for this Ligand-Target Pair | |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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Patents
Similars
| Article PubMed
| n/a | n/a | 2.43E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorimetric ... |
Bioorg Med Chem 25: 1997-2009 (2017)
Article DOI: 10.1016/j.bmc.2017.02.027 BindingDB Entry DOI: 10.7270/Q2Q81GBJ |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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Patents
Similars
| PDB Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorimetric ... |
Bioorg Med Chem 25: 1997-2009 (2017)
Article DOI: 10.1016/j.bmc.2017.02.027 BindingDB Entry DOI: 10.7270/Q2Q81GBJ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB US Patent
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
R-Tech Ueno, Ltd.
US Patent
| Assay Description The compounds of the present invention obtained in the Production Examples were examined for the inhibitory effect on human monoamineoxydase enzymes ... |
US Patent US9603833 (2017)
BindingDB Entry DOI: 10.7270/Q2W37ZCW |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate incubated for 30 mins by fluor... |
Eur J Med Chem 126: 762-775 (2017)
Article DOI: 10.1016/j.ejmech.2016.12.009 BindingDB Entry DOI: 10.7270/Q2NG4SW1 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| Article PubMed
| n/a | n/a | 4.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate incubated for 30 mins by fluor... |
Eur J Med Chem 126: 762-775 (2017)
Article DOI: 10.1016/j.ejmech.2016.12.009 BindingDB Entry DOI: 10.7270/Q2NG4SW1 |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A using kynuramine as substrate after 30 mins by fluorescence assay |
Bioorg Med Chem Lett 27: 718-722 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.050 BindingDB Entry DOI: 10.7270/Q2JM2CX6 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| Article PubMed
| n/a | n/a | 8.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-B using kynuramine as substrate after 30 mins by fluorescence assay |
Bioorg Med Chem Lett 27: 718-722 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.050 BindingDB Entry DOI: 10.7270/Q2JM2CX6 |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunchon National University
Curated by ChEMBL
| Assay Description Reversible inhibition of recombinant human MAO-A assessed as residual activity using kynuramine as substrate preincubated for 30 mins followed by dia... |
Bioorg Med Chem Lett 28: 2403-2407 (2018)
BindingDB Entry DOI: 10.7270/Q23R0WCT |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto
Curated by ChEMBL
| Assay Description Inhibition of human recombinant microsomal MAOA expressed in baculovirus infected BTI-TN-5B1- 4 cells using p-tyramine as substrate assessed as decre... |
J Med Chem 60: 7206-7212 (2017)
BindingDB Entry DOI: 10.7270/Q23B62KQ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanyang Normal University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence ... |
Bioorg Med Chem 25: 3006-3017 (2017)
BindingDB Entry DOI: 10.7270/Q2F76G04 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PubMed
| n/a | n/a | 5.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanyang Normal University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence ... |
Bioorg Med Chem 25: 3006-3017 (2017)
BindingDB Entry DOI: 10.7270/Q2F76G04 |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
University of the Western Cape
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A assessed as reduction in 4-hydroxyquinolone production using kynuramine as substrate after 20 mins by fluoresce... |
Eur J Med Chem 125: 853-864 (2017)
BindingDB Entry DOI: 10.7270/Q2BP057T |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Anadolu University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using tyramine as substrate pretreated for 30 mins followed ... |
Eur J Med Chem 131: 92-106 (2017)
BindingDB Entry DOI: 10.7270/Q2MG7RZB |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanyang Normal University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A using kynuramine as substrate after 30 mins by fluorescence method |
Bioorg Med Chem Lett 27: 5046-5052 (2017)
BindingDB Entry DOI: 10.7270/Q2XS5XTR |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 5.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanyang Normal University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-B using kynuramine as substrate after 30 mins by fluorescence method |
Bioorg Med Chem Lett 27: 5046-5052 (2017)
BindingDB Entry DOI: 10.7270/Q2XS5XTR |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Xinxiang Medical University
Curated by ChEMBL
| Assay Description Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assay |
Eur J Med Chem 140: 392-402 (2017)
BindingDB Entry DOI: 10.7270/Q2HH6NK6 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 6.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Government College University
Curated by ChEMBL
| Assay Description Inhibition of MAO-B in rat liver mitochondria using p-tyramine as substrate preincubated for 10 mins followed by substrate addition measured after 30... |
Eur J Med Chem 143: 1373-1386 (2018)
BindingDB Entry DOI: 10.7270/Q21V5HHC |
More data for this Ligand-Target Pair | |
Monoamine oxidase
(Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Government College University
Curated by ChEMBL
| Assay Description Inhibition of MAO-A in rat liver mitochondria using p-tyramine as substrate preincubated for 10 mins followed by substrate addition measured after 30... |
Eur J Med Chem 143: 1373-1386 (2018)
BindingDB Entry DOI: 10.7270/Q21V5HHC |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
"G. D'Annunzio" University of Chieti-Pescara
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A using kynuramine as substrate after 20 mins by fluorescence assay |
Eur J Med Chem 143: 1543-1552 (2018)
BindingDB Entry DOI: 10.7270/Q27H1N3J |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 6.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
"G. D'Annunzio" University of Chieti-Pescara
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-B using kynuramine as substrate after 20 mins by fluorescence assay |
Eur J Med Chem 143: 1543-1552 (2018)
BindingDB Entry DOI: 10.7270/Q27H1N3J |
More data for this Ligand-Target Pair | |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yonsei University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-B using benzylamine as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins b... |
Bioorg Med Chem 26: 232-244 (2018)
BindingDB Entry DOI: 10.7270/Q2959M4S |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Yonsei University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by... |
Bioorg Med Chem 26: 232-244 (2018)
BindingDB Entry DOI: 10.7270/Q2959M4S |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 189 | n/a | n/a | n/a | n/a | n/a | n/a |
Hefei University of Technology
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured over 15 mins by ... |
Eur J Med Chem 145: 588-593 (2018)
BindingDB Entry DOI: 10.7270/Q2JD50CJ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | >6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hefei University of Technology
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-B using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured over 15 mins by ... |
Eur J Med Chem 145: 588-593 (2018)
BindingDB Entry DOI: 10.7270/Q2JD50CJ |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence ... |
Bioorg Med Chem 26: 1102-1115 (2018)
BindingDB Entry DOI: 10.7270/Q2MW2KRT |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence ... |
Bioorg Med Chem 26: 1102-1115 (2018)
BindingDB Entry DOI: 10.7270/Q2MW2KRT |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar
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CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
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| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunchon National University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA using kynuramine as substrate preincubated for 30 mins followed by substrate addition |
Bioorg Med Chem Lett 28: 584-588 (2018)
BindingDB Entry DOI: 10.7270/Q25T3P2R |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar
| Purchase
CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars
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| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunchon National University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOB using benzylamine as substrate preincubated for 30 mins followed by substrate addition |
Bioorg Med Chem Lett 28: 584-588 (2018)
BindingDB Entry DOI: 10.7270/Q25T3P2R |
More data for this Ligand-Target Pair | |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar
| Purchase
CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 7.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using benzylamine as substrate preincubated for 1 h... |
J Med Chem 61: 7043-7064 (2018)
BindingDB Entry DOI: 10.7270/Q2VT1VSP |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar
| Purchase
CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using tyramine as substrate preincubated for 1 hr f... |
J Med Chem 61: 7043-7064 (2018)
BindingDB Entry DOI: 10.7270/Q2VT1VSP |
More data for this Ligand-Target Pair |  3D Structure (crystal) |