BDBM160103 US10047092, 44::US10053463, 44::US9040534, 44

SMILES C[C@H]1Cn2c(nnc2-c2cccnn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F

InChI Key InChIKey=VIQPIXUMNSQISL-JTQLQIEISA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 160103   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160103(US10047092, 44 | US10053463, 44 | US9040534, 44)
Affinity DataIC50:  177nMpH: 7.4Assay Description:Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160103(US10047092, 44 | US10053463, 44 | US9040534, 44)
Affinity DataIC50:  1.99E+4nMpH: 7.4Assay Description:Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Mus musculus)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160103(US10047092, 44 | US10053463, 44 | US9040534, 44)
Affinity DataIC50:  1.99E+4nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160103(US10047092, 44 | US10053463, 44 | US9040534, 44)
Affinity DataIC50:  1.99E+4nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160103(US10047092, 44 | US10053463, 44 | US9040534, 44)
Affinity DataIC50:  177nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM160103(US10047092, 44 | US10053463, 44 | US9040534, 44)
Affinity DataIC50:  177nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In DepthDetails US Patent