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BDBM160641 US9682980, 8-Chloro-3-(cyclopropylmethyl)-N-(((1S,2S)-2-(4-fluorophenyl)cyclopropyl)methyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-amine

SMILES: Cc1c(NC[C@H]2C[C@H]2c2ccc(F)cc2)cnn2c(CC3CC3)nnc12

InChI Key: InChIKey=AHKOVEKGGNOLDY-WBVHZDCISA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160641   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160641
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-N-(((1S,...)
Show SMILES Cc1c(NC[C@H]2C[C@H]2c2ccc(F)cc2)cnn2c(CC3CC3)nnc12
Show InChI InChI=1S/C20H22FN5/c1-12-18(11-23-26-19(8-13-2-3-13)24-25-20(12)26)22-10-15-9-17(15)14-4-6-16(21)7-5-14/h4-7,11,13,15,17,22H,2-3,8-10H2,1H3/t15-,17+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/an/an/a 60n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair