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BDBM160719 US9682980, 7-(4-(4-Fluorophenyl)piperidin-1-yl)-8-methoxy-3-neopentyl-[1,2,4]triazolo[4,3-c]pyrimidine

SMILES: COc1c(ncn2c(CC(C)(C)C)nnc12)N1CCC(CC1)c1ccc(F)cc1

InChI Key: InChIKey=JWDNYQHMECYRLP-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160719   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160719
PNG
(US9682980, 7-(4-(4-Fluorophenyl)piperidin-1-yl)-8-...)
Show SMILES COc1c(ncn2c(CC(C)(C)C)nnc12)N1CCC(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C22H28FN5O/c1-22(2,3)13-18-25-26-21-19(29-4)20(24-14-28(18)21)27-11-9-16(10-12-27)15-5-7-17(23)8-6-15/h5-8,14,16H,9-13H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 286n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair