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BDBM160720 US9682980, 1-(3-(Cyclopropylmethyl)-8-methoxy-[1,2,4]triazolo[4,3-c]pyrimidin-7-yl)-4-(4-fluorophenyl)piperidin-4-ol

SMILES: OC1(CCN(CC1)c1ncn2c(CC3CC3)nnc2c1Cl)c1ccc(F)cc1

InChI Key: InChIKey=UXWIEORYISWVTJ-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160720   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160720
PNG
(US9682980, 1-(3-(Cyclopropylmethyl)-8-methoxy-[1,2...)
Show SMILES OC1(CCN(CC1)c1ncn2c(CC3CC3)nnc2c1Cl)c1ccc(F)cc1
Show InChI InChI=1S/C20H21ClFN5O/c21-17-18(23-12-27-16(11-13-1-2-13)24-25-19(17)27)26-9-7-20(28,8-10-26)14-3-5-15(22)6-4-14/h3-6,12-13,28H,1-2,7-11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/an/an/a 782n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair