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BDBM160727 US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(4-fluorophenyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine

SMILES: Fc1ccc(cc1)N1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl

InChI Key: InChIKey=RMJSCCTZTKHKGT-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160727   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160727
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(4-...)
Show SMILES Fc1ccc(cc1)N1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C19H20ClFN6/c20-18-16(12-22-27-17(11-13-1-2-13)23-24-19(18)27)26-9-7-25(8-10-26)15-5-3-14(21)4-6-15/h3-6,12-13H,1-2,7-11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 614n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair