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BDBM160738 US9682980, 8-Chloro-3-(cyclopropylmethyl)-N-((1-(phenoxymethyl)cyclopropyl)methyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-amine

SMILES: Clc1c(NCC2(COc3ccccc3)CC2)cnn2c(CC3CC3)nnc12

InChI Key: InChIKey=WYMSJNBDOXAXGV-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160738   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160738
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-N-((1-(p...)
Show SMILES Clc1c(NCC2(COc3ccccc3)CC2)cnn2c(CC3CC3)nnc12
Show InChI InChI=1S/C20H22ClN5O/c21-18-16(11-23-26-17(10-14-6-7-14)24-25-19(18)26)22-12-20(8-9-20)13-27-15-4-2-1-3-5-15/h1-5,11,14,22H,6-10,12-13H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.31E+3n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair