BindingDB logo
myBDB logout

BDBM160759 US9682980, 8-Chloro-N-((2-(2-fluoro-6-methoxyphenyl)cyclopropyl)methyl)-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-amine

SMILES: COc1cccc(F)c1C1CC1CNc1cnn2c(CC(F)(F)F)nnc2c1Cl

InChI Key: InChIKey=JFHXBFKFLTUNEE-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160759   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160759
PNG
(US9682980, 8-Chloro-N-((2-(2-fluoro-6-methoxypheny...)
Show SMILES COc1cccc(F)c1C1CC1CNc1cnn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1S/C18H16ClF4N5O/c1-29-13-4-2-3-11(20)15(13)10-5-9(10)7-24-12-8-25-28-14(6-18(21,22)23)26-27-17(28)16(12)19/h2-4,8-10,24H,5-7H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/an/an/a 31n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair