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BDBM160761 US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(4,6-dimethoxypyrimidin-2-yl)piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine

SMILES: COc1cc(OC)nc(n1)C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl

InChI Key: InChIKey=HUIAXIVKYLDAQB-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160761   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160761
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(4,...)
Show SMILES COc1cc(OC)nc(n1)C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C20H24ClN7O2/c1-29-16-10-17(30-2)24-19(23-16)13-5-7-27(8-6-13)14-11-22-28-15(9-12-3-4-12)25-26-20(28)18(14)21/h10-13H,3-9H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 11n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair