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BDBM160797 US9682980, 8-Chloro-3-(2,2,2-trifluoroethyl)-7-(4-(2-(trifluoromethyl)phenyl)piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine

SMILES: FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccc1C(F)(F)F

InChI Key: InChIKey=FPQNVKKAJLDEAK-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160797   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160797
PNG
(US9682980, 8-Chloro-3-(2,2,2-trifluoroethyl)-7-(4-...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C19H16ClF6N5/c20-16-14(10-27-31-15(9-18(21,22)23)28-29-17(16)31)30-7-5-11(6-8-30)12-3-1-2-4-13(12)19(24,25)26/h1-4,10-11H,5-9H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/an/an/a 23n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair