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BDBM160817 US9682980, 2-(1-(3-(Cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)piperidin-4-yl)benzonitrile

SMILES: FC(F)(F)c1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1C#N

InChI Key: InChIKey=MOFHAUBPYLFGHT-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160817   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160817
PNG
(US9682980, 2-(1-(3-(Cyclopropylmethyl)-8-(trifluor...)
Show SMILES FC(F)(F)c1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1C#N
Show InChI InChI=1S/C22H21F3N6/c23-22(24,25)20-18(13-27-31-19(11-14-5-6-14)28-29-21(20)31)30-9-7-15(8-10-30)17-4-2-1-3-16(17)12-26/h1-4,13-15H,5-11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/an/an/a 4n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair