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BDBM160820 US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(pyridin-2-yl)piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine

SMILES: Clc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccn1

InChI Key: InChIKey=NZDCDXXTRIVSAC-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160820   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160820
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(py...)
Show SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccn1
Show InChI InChI=1S/C19H21ClN6/c20-18-16(12-22-26-17(11-13-4-5-13)23-24-19(18)26)25-9-6-14(7-10-25)15-3-1-2-8-21-15/h1-3,8,12-14H,4-7,9-11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 382n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair