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BDBM160825 US9682980, 8-Chloro-7-(4-(3-methoxypyridin-2-yl)piperidin-1-yl)-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-b]pyridazine

SMILES: FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccn1

InChI Key: InChIKey=YOZHPQISORPVGD-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160825   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160825
PNG
(US9682980, 8-Chloro-7-(4-(3-methoxypyridin-2-yl)pi...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccn1
Show InChI InChI=1S/C17H16ClF3N6/c18-15-13(10-23-27-14(9-17(19,20)21)24-25-16(15)27)26-7-4-11(5-8-26)12-3-1-2-6-22-12/h1-3,6,10-11H,4-5,7-9H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 42n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair