BindingDB logo
myBDB logout

BDBM160828 US9682980, Trans-N-((2-(2-methoxyphenyl)cyclopropyl)methyl)-3-(2,2,2-trifluoroethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-amine

SMILES: COc1ccccc1C1CC1CNc1cnn2c(CC(F)(F)F)nnc2c1C(F)(F)F

InChI Key: InChIKey=ZOEFNDKIQQZQDY-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160828   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160828
PNG
(US9682980, Trans-N-((2-(2-methoxyphenyl)cyclopropy...)
Show SMILES COc1ccccc1C1CC1CNc1cnn2c(CC(F)(F)F)nnc2c1C(F)(F)F
Show InChI InChI=1S/C19H17F6N5O/c1-31-14-5-3-2-4-11(14)12-6-10(12)8-26-13-9-27-30-15(7-18(20,21)22)28-29-17(30)16(13)19(23,24)25/h2-5,9-10,12,26H,6-8H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 10n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair