BDBM16111 2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}cyclopent-1-ene-1-carboxylic acid::Biphenyl-4-ylcarbamoyl Cyclopentene Analog 2::CHEMBL197194
SMILES COc1cccc(c1)-c1ccc(NC(=O)C2=C(CCC2)C(O)=O)c(F)c1
InChI Key InChIKey=XPRDUGXOWVXZLL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 16111
Affinity DataIC50: 134nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc
Curated by ChEMBL
4Sc
Curated by ChEMBL
Affinity DataIC50: 134nMAssay Description:Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assayMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc
Curated by ChEMBL
4Sc
Curated by ChEMBL
Affinity DataIC50: 134nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate by DCIP dye based spectrophotometry analysisMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc
Curated by ChEMBL
4Sc
Curated by ChEMBL
Affinity DataEC50: 2.75E+3nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
TargetBifunctional peptidase and (3S)-lysyl hydroxylase JMJD7(Homo sapiens)
Sichuan University
Curated by ChEMBL
Sichuan University
Curated by ChEMBL
Affinity DataIC50: 7.16E+3nMAssay Description:Inhibition of N-terminal His-tagged human JMJD7 (1 to 316 residues) expressed in Escherichia coli BL21 (DE3) luciferase based succinate-gloTM JmjC de...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
4Sc
Curated by ChEMBL
4Sc
Curated by ChEMBL
Affinity DataEC50: 2.80E+3nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair