BDBM161361 US10087143, Compound 146::US10738009, Compound 146::US11673864, Compound 146::US9051270, 146::US9758483, Compound 146

SMILES Cc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cn1

InChI Key InChIKey=GVUYQPUAVUSQLF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 161361   

TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161361(US10087143, Compound 146 | US10738009, Compound 14...)
Affinity DataIC50:  4.60E+3nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161361(US10087143, Compound 146 | US10738009, Compound 14...)
Affinity DataIC50:  4.60E+3nMAssay Description:Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161361(US10087143, Compound 146 | US10738009, Compound 14...)
Affinity DataIC50:  4.60E+3nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161361(US10087143, Compound 146 | US10738009, Compound 14...)
Affinity DataIC50:  4.60E+3nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161361(US10087143, Compound 146 | US10738009, Compound 14...)
Affinity DataIC50:  4.60E+3nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In DepthDetails US Patent