BDBM162230 US9669028, 59 2-(4-(6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)piperazin-1-yl)ethanol

SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCN(CCO)CC1

InChI Key InChIKey=GMLOGFGVWLZTGE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 162230   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM162230(US9669028, 59 2-(4-(6-(3-methyl-1H-pyrazolo[3,4-b]...)
Affinity DataIC50: <500nMAssay Description:Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM162230(US9669028, 59 2-(4-(6-(3-methyl-1H-pyrazolo[3,4-b]...)
Affinity DataIC50: >500nMpH: 7.5Assay Description:The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM162230(US9669028, 59 2-(4-(6-(3-methyl-1H-pyrazolo[3,4-b]...)
Affinity DataIC50: <500nMAssay Description:Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent