BDBM162328 US9669028, 77 (6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)(piperidin-1-yl)methanone

SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)C(=O)N1CCCCC1

InChI Key InChIKey=VSYBVYRURFUDHW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 162328   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM162328(US9669028, 77 (6-(3-methyl-1H-pyrazolo[3,4-b]pyrid...)
Affinity DataIC50: >500nMAssay Description:Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM162328(US9669028, 77 (6-(3-methyl-1H-pyrazolo[3,4-b]pyrid...)
Affinity DataIC50: >1.00E+3nMpH: 7.5Assay Description:The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM162328(US9669028, 77 (6-(3-methyl-1H-pyrazolo[3,4-b]pyrid...)
Affinity DataIC50: >500nMAssay Description:Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent