BDBM162601 US9687479, 81 3-(5-[(5-chlorothiophen-2-yl)methyl]amino-1-(2,2-dimethylpropanoyl)-1H-pyrazol-3-yl)-1-(pyridazin-3-ylmethyl)-1,2-dihydropyridin-2-one

SMILES CC(C)(C)C(=O)n1nc(cc1NCc1ccc(Cl)s1)-c1cccn(Cc2cccnn2)c1=O

InChI Key InChIKey=YEQOTFQTNRMTMJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 162601   

TargetProthrombin(Homo sapiens (Human))
Verseon

US Patent
LigandPNGBDBM162601(US9687479, 81 3-(5-[(5-chlorothiophen-2-yl)methyl]...)
Affinity DataIC50: <100nMpH: 7.4 T: 2°CAssay Description:Human thrombin was obtained from Haematologic Technologies Inc. The chromogenic substrate S-2238 was obtained from DiaPharma. Thrombin was assayed in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Verseon

US Patent
LigandPNGBDBM162601(US9687479, 81 3-(5-[(5-chlorothiophen-2-yl)methyl]...)
Affinity DataIC50:  5.50E+3nMpH: 7.4 T: 2°CAssay Description:Human KLKB1 protein was obtained from Enzyme Research Labs. The chromogenic substrate S-2302 was obtained from DiaPharma. KLKB1 was assayed in buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Verseon

US Patent
LigandPNGBDBM162601(US9687479, 81 3-(5-[(5-chlorothiophen-2-yl)methyl]...)
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent