BDBM162646 US9687479, 126 3-(5-[(5-chlorothiophen-2-yl)methyl]amino-1-[(2,4-dimethoxyphenyl)carbonyl]-1H-pyrazol-3-yl)-1-(pyridin-3-ylmethyl)-1,2-dihydropyridin-2-one

SMILES COc1ccc(C(=O)n2nc(cc2NCc2ccc(Cl)s2)-c2cccn(Cc3cccnc3)c2=O)c(OC)c1

InChI Key InChIKey=YFQJGNJWXSYLMF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 162646   

TargetProthrombin(Homo sapiens (Human))
Verseon

US Patent
LigandPNGBDBM162646(US9687479, 126 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: <100nMpH: 7.4 T: 2°CAssay Description:Human thrombin was obtained from Haematologic Technologies Inc. The chromogenic substrate S-2238 was obtained from DiaPharma. Thrombin was assayed in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Verseon

US Patent
LigandPNGBDBM162646(US9687479, 126 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50:  5.50E+3nMpH: 7.4 T: 2°CAssay Description:Human KLKB1 protein was obtained from Enzyme Research Labs. The chromogenic substrate S-2302 was obtained from DiaPharma. KLKB1 was assayed in buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Verseon

US Patent
LigandPNGBDBM162646(US9687479, 126 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent