BDBM16316 3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-methyl-1,4-diazepan-1-yl)-1,3,5-triazin-2-yl}amino)-N-methoxy-4-methylbenzamide::CHEMBL225088::triaminotriazine aniline amide inhibitor, 1

SMILES CONC(=O)c1ccc(C)c(Nc2nc(nc(n2)N2CCCN(C)CC2)N(C)CC(C)(C)C)c1

InChI Key InChIKey=CFXVMISMBBBSCO-UHFFFAOYSA-N

Data  1 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 16316   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataKi:  3.70nM ΔG°:  -11.4kcal/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Zap70More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKCdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human IKK2betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM16316(3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-met...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed