BDBM164104 US9687479, 384 N-[(5-chlorothiophen-2-yl)methyl]-1-[(2,4-dimethoxyphenyl)carbonyl]-3-(oxan-4-yl)-1H-1,2,4-triazol-5-amine

SMILES COc1ccc(C(=O)n2nc(nc2NCc2ccc(Cl)s2)C2CCOCC2)c(OC)c1

InChI Key InChIKey=KVIQDQUIYIPWCU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 164104   

TargetPlasma kallikrein(Homo sapiens (Human))
Verseon

US Patent
LigandPNGBDBM164104(US9687479, 384 N-[(5-chlorothiophen-2-yl)methyl]-1...)
Affinity DataIC50:  550nMpH: 7.4 T: 2°CAssay Description:Human KLKB1 protein was obtained from Enzyme Research Labs. The chromogenic substrate S-2302 was obtained from DiaPharma. KLKB1 was assayed in buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Verseon

US Patent
LigandPNGBDBM164104(US9687479, 384 N-[(5-chlorothiophen-2-yl)methyl]-1...)
Affinity DataIC50:  5.50E+4nMpH: 7.5 T: 2°CAssay Description:Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent