BDBM16654 1-phenyl-3-(4-sulfamoylphenyl)urea::aromatic sulfonamide compound 19

SMILES NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2)cc1

InChI Key InChIKey=XCGMCYYUHKUQTO-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 16654   

TargetCarbonic anhydrase 5A, mitochondrial(Mus musculus (mouse))
Universita Degli Studi Di Firenze

LigandPNGBDBM16654(1-phenyl-3-(4-sulfamoylphenyl)urea | aromatic sulf...)
Affinity DataKi:  21nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universita` Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM16654(1-phenyl-3-(4-sulfamoylphenyl)urea | aromatic sulf...)
Affinity DataKi:  67nMAssay Description:Inhibition of tumor-associated human carbonic anhydrase 12 preincubated for 15 min by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM16654(1-phenyl-3-(4-sulfamoylphenyl)urea | aromatic sulf...)
Affinity DataKi:  240nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-carbonic anhydrase 1(Mycobacterium tuberculosis)
Universit£

Curated by ChEMBL
LigandPNGBDBM16654(1-phenyl-3-(4-sulfamoylphenyl)urea | aromatic sulf...)
Affinity DataKi:  356nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
Universita Degli Studi Di Firenze

LigandPNGBDBM16654(1-phenyl-3-(4-sulfamoylphenyl)urea | aromatic sulf...)
Affinity DataKi:  460nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universita` Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM16654(1-phenyl-3-(4-sulfamoylphenyl)urea | aromatic sulf...)
Affinity DataKi:  575nMAssay Description:Inhibition of tumor-associated human carbonic anhydrase 9 preincubated for 15 min by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Mycobacterium tuberculosis)
Universit£

Curated by ChEMBL
LigandPNGBDBM16654(1-phenyl-3-(4-sulfamoylphenyl)urea | aromatic sulf...)
Affinity DataKi:  758nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv3273 preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita` Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM16654(1-phenyl-3-(4-sulfamoylphenyl)urea | aromatic sulf...)
Affinity DataKi:  760nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 min by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita` Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM16654(1-phenyl-3-(4-sulfamoylphenyl)urea | aromatic sulf...)
Affinity DataKi:  1.20E+3nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM16654(1-phenyl-3-(4-sulfamoylphenyl)urea | aromatic sulf...)
Affinity DataKi:  3.73E+3nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 min by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM16654(1-phenyl-3-(4-sulfamoylphenyl)urea | aromatic sulf...)
Affinity DataKi:  3.73E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed