BDBM168127 US9073936, 2::US9598426, 2
SMILES: CC(O)c1ccc(Cn2nc3N4CC(C)(C)N=C4N(C)C(=O)c3c2Nc2ccc(F)cc2)cc1
InChI Key: InChIKey=PSUHAEXBWCRQED-UHFFFAOYNA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase 1A (PDE1A) (Homo sapiens (Human)) | BDBM168127![]() (US9073936, 2 | US9598426, 2) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article US Patent | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Intra-Cellular Therapies Inc US Patent | Assay Description Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L... | US Patent US9598426 (2017) Article DOI: 10.1021/jm030933g BindingDB Entry DOI: 10.7270/Q29S1T2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 1A (PDE1A) (Homo sapiens (Human)) | BDBM168127![]() (US9073936, 2 | US9598426, 2) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar | PC cid PC sid UniChem Similars | US Patent | 0.5 | -12.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 30 |
Intra-Cellular Therapies Inc US Patent | Assay Description Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP... | US Patent US9073936 (2015) BindingDB Entry DOI: 10.7270/Q2348J5T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human)) | BDBM168127![]() (US9073936, 2 | US9598426, 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem Similars | Article US Patent | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Intra-Cellular Therapies Inc US Patent | US Patent US9598426 (2017) Article DOI: 10.1021/jm030933g BindingDB Entry DOI: 10.7270/Q29S1T2J | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 1A (PDE1A) (Homo sapiens (Human)) | BDBM168127![]() (US9073936, 2 | US9598426, 2) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar | PC cid PC sid UniChem Similars | US Patent | 4 | -11.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 30 |
Intra-Cellular Therapies Inc US Patent | Assay Description Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP... | US Patent US9073936 (2015) BindingDB Entry DOI: 10.7270/Q2348J5T | |||||||||||
More data for this Ligand-Target Pair |