BDBM170514 US9085540, 54

SMILES CCc1nc(C(N)=O)c(Nc2ccc(cc2)N2CCC(CC2)N2CCN(C)CC2)nc1O[C@@H]1CCN(C1)C(=O)C=C

InChI Key InChIKey=QKDCLUARMDUUKN-XMMPIXPASA-N

Data  7 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 170514   

TargetEpidermal growth factor receptor(Human)
Astellas Pharma

US Patent
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50:  1.70nMAssay Description:The phosphorylation activity on the peptide substrate of EGFR was investigated using LabChip (trademark) Systems (Caliper Life Sciences, Inc.). For t...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Astellas Pharma

US Patent
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50:  4.5nMAssay Description:The phosphorylation activity on the peptide substrate of EGFR was investigated using LabChip (trademark) Systems (Caliper Life Sciences, Inc.). For t...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50:  8nMAssay Description:Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Astellas Pharma

US Patent
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50:  230nMAssay Description:Inhibition of wild type EGFR in human NCI-H1666 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50:  8nMAssay Description:Inhibition of EGFR Del ex19 mutant in human PC9 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50:  8nMAssay Description:Inhibition of EGFR Del ex19/T790M double mutant in human PC9 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM170514(US9085540, 54)
Affinity DataIC50:  8nMAssay Description:Inhibition of EGFR Del ex19 mutant in human HCC827 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair