BDBM17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999
SMILES: CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21
InChI Key: InChIKey=ZCBUQCWBWNUWSU-SFHVURJKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ribosomal protein S6 kinase alpha 2 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | 2.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1074/jbc.M111.279984 BindingDB Entry DOI: 10.7270/Q25D8Q75 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase alpha 1 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1074/jbc.M111.274068 BindingDB Entry DOI: 10.7270/Q2959FZG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | 4.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2GB22FT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | 9.20E+5 | -4.14 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase alpha 6 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | 2.30E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2WW7G1J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase alpha-3 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | 3.60E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1074/jbc.M109.039511 BindingDB Entry DOI: 10.7270/Q21N7ZHF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-phosphoinositide-dependent protein kinase 1 (aa 51-359) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (L159M) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (A162V) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 743 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (E166D) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 610 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (T222A) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 734 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T/T222A) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
CLK1 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD DrugBank GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 910 | n/a | n/a | n/a | 7.4 | 23 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase CLK4 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | 7.4 | 23 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 15 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | KEGG UniProtKB/SwissProt GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 88 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine Kinase FLT3 Mutant (N841I) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 980 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
FLT3(D835H) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 210 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
FLT3(D835Y) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 130 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase receptor FLT3 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 280 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CaM-kinase kinase alpha (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1016/j.bioorg.2011.10.003 BindingDB Entry DOI: 10.7270/Q237773V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CaM-kinase kinase beta (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1016/j.bioorg.2012.01.003 BindingDB Entry DOI: 10.7270/Q2ZG6QM5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase CLK2 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1016/j.bmcl.2007.11.068 BindingDB Entry DOI: 10.7270/Q2FJ2F5J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase GAK (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q20863ND | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase LATS1 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2319T7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-dependent protein kinase (PKA) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2J38QW0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C theta type (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2DB8052 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase D2 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q24T6GR2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PLK4 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2J101JH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP4K1 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1124/jpet.104.066688 BindingDB Entry DOI: 10.7270/Q2MG7MVB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 3 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1124/jpet.104.066761 BindingDB Entry DOI: 10.7270/Q2GQ6W41 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual-specificity tyrosine-regulated kinases 1B (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1080/14756360801945598 BindingDB Entry DOI: 10.7270/Q27H1GZP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Axin-1/Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1080/14756360802187612 BindingDB Entry DOI: 10.7270/Q2KS6PZX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphorylase kinase (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1080/14756360802218441 BindingDB Entry DOI: 10.7270/Q22R3Q13 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NUAK family SNF1-like kinase 2 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1080/14756360802236393 BindingDB Entry DOI: 10.7270/Q2Z036J3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MST2 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1124/jpet.104.070086 BindingDB Entry DOI: 10.7270/Q2KH0KP2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AP2-associated protein kinase 1 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1080/14756360802316971 BindingDB Entry DOI: 10.7270/Q2TB158J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NUAK family SNF1-like kinase 1 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2JS9NTJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BIKE (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2F18X3J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1/2 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q29885C6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Casein kinase II subunit alpha (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q25H7DNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Casein kinase II subunit alpha' (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q21R6NXR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-dependent protein kinase (PKA) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1038/sj.bjp.0705908 BindingDB Entry DOI: 10.7270/Q22J697W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RPS6KA4(Kin.Dom.1 - N-terminal) (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1038/sj.bjp.0705964 BindingDB Entry DOI: 10.7270/Q2DV1H84 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase alpha 5 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2930RJQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1038/nchembio.662 BindingDB Entry DOI: 10.7270/Q25B00TC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLK1 (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1074/jbc.M112.356576 BindingDB Entry DOI: 10.7270/Q2C24TTX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myosin light chain kinase, smooth muscle (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1074/jbc.M110.211417 BindingDB Entry DOI: 10.7270/Q2V40SMB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PCBioAssay | n/a | n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1074/jbc.M111.251710 BindingDB Entry DOI: 10.7270/Q22N50PN | |||||||||||
More data for this Ligand-Target Pair |
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