BDBM173852 US9102591, (+)2,3-dichloro-N-[3-cyclopropyl-2-[6-(difluoromethyl)-3-pyridyl]propyl]benzamide::US9649308, (-)2,3-dichloro-N-[3-cyclopropyl-2-[6-(difluoromethyl)-3-pyridyl]propyl]benzamide

SMILES FC(F)c1ccc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)CC1CC1

InChI Key InChIKey=QHYHEDBLTNQEBW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 173852   

TargetP2X purinoceptor 7(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM173852(US9102591, (+)2,3-dichloro-N-[3-cyclopropyl-2-[6-(...)
Affinity DataIC50:  24nMpH: 7.4 T: 2°CAssay Description:Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM173852(US9102591, (+)2,3-dichloro-N-[3-cyclopropyl-2-[6-(...)
Affinity DataIC50:  1.90nMAssay Description:Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM173852(US9102591, (+)2,3-dichloro-N-[3-cyclopropyl-2-[6-(...)
Affinity DataIC50:  24nMAssay Description:Fluorescent Imaging Plate Reader (FLIPR) assay: Briefly, 293-human or mouse P2X7 stable cells were incubated in sucrose buffer, pH 7.4 [KCl (5 mM), N...More data for this Ligand-Target Pair
In DepthDetails US Patent