BDBM17663 (2S)-2-amino-3-(sulfooxy)propanoic acid::L-SOS::L-serine O-sulfate::Sulfoserine
SMILES: N[C@@H](COS(O)(=O)=O)C(O)=O
InChI Key: InChIKey=LFZGUGJDVUUGLK-REOHCLBHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gamma-amino-N-butyrate transaminase (Sus scrofa) | BDBM17663![]() ((2S)-2-amino-3-(sulfooxy)propanoic acid | L-SOS | ...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Patents | Article | 2.40E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Apparent dissociation constants for inactivation of Gamma-amino-N-butyrate transaminase | Bioorg Med Chem Lett 2: 1371-1374 (1992) Article DOI: 10.1016/S0960-894X(00)80515-6 BindingDB Entry DOI: 10.7270/Q2251JNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 1 (Homo sapiens (Human)) | BDBM17663![]() ((2S)-2-amino-3-(sulfooxy)propanoic acid | L-SOS | ...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells | J Med Chem 52: 912-5 (2009) Article DOI: 10.1021/jm8013458 BindingDB Entry DOI: 10.7270/Q2PV6KCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystine/glutamate transporter (Homo sapiens (Human)) | BDBM17663![]() ((2S)-2-amino-3-(sulfooxy)propanoic acid | L-SOS | ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Montana Curated by ChEMBL | Assay Description Inhibition of amino acid transport system xc- | Bioorg Med Chem Lett 20: 2680-3 (2010) Article DOI: 10.1016/j.bmcl.2009.10.020 BindingDB Entry DOI: 10.7270/Q29Z952F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate Carboxypeptidase II (GCPII) (Homo sapiens (Human)) | BDBM17663![]() ((2S)-2-amino-3-(sulfooxy)propanoic acid | L-SOS | ...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar | Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB Article PubMed | n/a | n/a | 4.38E+5 | n/a | n/a | n/a | n/a | 7.4 | 37 |
NCI-FCRDC | Assay Description The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ... | J Med Chem 50: 3267-73 (2007) Article DOI: 10.1021/jm070133w BindingDB Entry DOI: 10.7270/Q29C6VPS | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Excitatory amino acid transporter 3 (Homo sapiens (Human)) | BDBM17663![]() ((2S)-2-amino-3-(sulfooxy)propanoic acid | L-SOS | ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEBI KEGG MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells | J Med Chem 52: 912-5 (2009) Article DOI: 10.1021/jm8013458 BindingDB Entry DOI: 10.7270/Q2PV6KCP | |||||||||||
More data for this Ligand-Target Pair |