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BDBM176730 US9688710, 151 2,2-dimethyl-3-(4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamido)propanoic acid

SMILES: CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCC(C)(C)C(O)=O)cc2)c1

InChI Key: InChIKey=HBQFAZYMMXPIHU-IONQDRQYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 176730   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM176730
PNG
(US9688710, 151 2,2-dimethyl-3-(4-(4-(2-methyl-5-((...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCC(C)(C)C(O)=O)cc2)c1
Show InChI InChI=1S/C29H39NO7S/c1-17-8-13-20(26-24(33)23(32)25(34)27(37-26)38-4)15-21(17)14-19-11-9-18(10-12-19)6-5-7-22(31)30-16-29(2,3)28(35)36/h8-13,15,23-27,32-34H,5-7,14,16H2,1-4H3,(H,30,31)(H,35,36)/t23-,24-,25+,26+,27-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM176730
PNG
(US9688710, 151 2,2-dimethyl-3-(4-(4-(2-methyl-5-((...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NCC(C)(C)C(O)=O)cc2)c1
Show InChI InChI=1S/C29H39NO7S/c1-17-8-13-20(26-24(33)23(32)25(34)27(37-26)38-4)15-21(17)14-19-11-9-18(10-12-19)6-5-7-22(31)30-16-29(2,3)28(35)36/h8-13,15,23-27,32-34H,5-7,14,16H2,1-4H3,(H,30,31)(H,35,36)/t23-,24-,25+,26+,27-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...


US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair