BDBM179474 US9675697, Cpd. No. 25

SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)nnc3-c3ccccc3)c21

InChI Key InChIKey=RYNCHXWJOVBAEO-PNHLSOANSA-N

Data  6 KI  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 179474   

TargetBromodomain-containing protein 3 [326-398](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKi:  9.40nM ΔG°:  -10.9kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3 [51-123](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKi:  10nM ΔG°:  -10.9kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [91-163](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKi:  12nM ΔG°:  -10.8kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [364-436](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKi:  22nM ΔG°:  -10.4kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKi:  27nM ΔG°:  -10.3kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [364-436](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKi:  38nM ΔG°:  -10.1kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKd:  60nMpH: 7.4Assay Description:Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3 [326-398](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKd:  42nMpH: 7.4Assay Description:Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3 [51-123](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKd:  21nMpH: 7.4Assay Description:Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [364-436](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKd:  36nMpH: 7.4Assay Description:Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [91-163](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKd:  41nMpH: 7.4Assay Description:Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [364-436](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM179474(US9675697, Cpd. No. 25)
Affinity DataKd:  36nMpH: 7.4Assay Description:Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent