BDBM18046 5-((4-methylphenyl)thio)-quinazoline 2,4-diamine, 1::5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE::5-[(4-methylphenyl)sulfanyl]quinazoline-2,4-diamine::5-[(4-methylphenyl)sulfanyl]quinazoline-2,4-diamine, 2c::CHEMBL83547::GW578
SMILES Cc1ccc(Sc2cccc3nc(N)nc(N)c23)cc1
InChI Key InChIKey=UOJFGEAPSYQDIP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 18046
Affinity DataKi: 73nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Inhibition assay using Esherichia coli dihydrofolate reductase (DHFR). More data for this Ligand-Target Pair
Affinity DataIC50: 820nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 100 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of Escherichia coli Dihydrofolate reductase in presence of 30 uM Dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 940nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMpH: 6.4 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Research Institute, Hospital For Sick Children
Research Institute, Hospital For Sick Children
Affinity DataIC50: 7.80E+3nMpH: 5.5 T: 2°CAssay Description:Beta-glucocerebrosidase (GCase) activity was measured by release of 4-methylumbelliferyl fluorophore from MUClc.More data for this Ligand-Target Pair