BDBM18243 6-[(5-iodo-2-methoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine::Piritrexim analogue, 55

SMILES COc1ccc(I)cc1Cc1cnc2nc(N)nc(N)c2c1C

InChI Key InChIKey=CFTCUSCIZZTKPF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18243   

TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

LigandPNGBDBM18243(6-[(5-iodo-2-methoxyphenyl)methyl]-5-methylpyrido[...)
Affinity DataIC50:  5.80nMpH: 7.4 T: 2°CAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

LigandPNGBDBM18243(6-[(5-iodo-2-methoxyphenyl)methyl]-5-methylpyrido[...)
Affinity DataIC50:  5nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

LigandPNGBDBM18243(6-[(5-iodo-2-methoxyphenyl)methyl]-5-methylpyrido[...)
Affinity DataIC50:  0.920nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

LigandPNGBDBM18243(6-[(5-iodo-2-methoxyphenyl)methyl]-5-methylpyrido[...)
Affinity DataIC50:  4.10nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed