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BDBM182949 US9670142, A11 4-(1H-imidazol-2-yl)-N-methyl-N-((1R,3S)-3-propionylamino-cyclopentyl)-benzamide

SMILES: CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ncc[nH]1

InChI Key: InChIKey=LKDBLEWIIHXFOZ-JKSUJKDBSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 182949   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty acid synthase (FAS)


(Homo sapiens (Human))
BDBM182949
PNG
(US9670142, A11 4-(1H-imidazol-2-yl)-N-methyl-N-((1...)
Show SMILES CCC(=O)N[C@H]1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-c1ncc[nH]1
Show InChI InChI=1S/C19H24N4O2/c1-3-17(24)22-15-8-9-16(12-15)23(2)19(25)14-6-4-13(5-7-14)18-20-10-11-21-18/h4-7,10-11,15-16H,3,8-9,12H2,1-2H3,(H,20,21)(H,22,24)/t15-,16+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 2.65E+4n/an/an/an/a7.025



Merck Patent GmbH

US Patent


Assay Description
The biochemical FASN activity testing was performed as 384 well two-time-point kinetic fluorescence intensity assay format in Greiner low volume medi...


US Patent US9670142 (2017)


BindingDB Entry DOI: 10.7270/Q2JW8C21
More data for this
Ligand-Target Pair