BDBM18387 Alkyl substituted pyrrole compound, 29d::sodium (3R,5R)-7-[1-ethyl-3-(4-fluorophenyl)-5-({[4-(methoxycarbonyl)phenyl]methyl}carbamoyl)-4-methyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoate

SMILES CCn1c(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c(c(C)c1C(=O)NCc1ccc(cc1)C(=O)OC)-c1ccc(F)cc1

InChI Key InChIKey=PQMAYIKJNUIXMQ-DNQXCXABSA-M

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 18387   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM18387(Alkyl substituted pyrrole compound, 29d | sodium (...)
Affinity DataIC50:  1.60nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed