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BDBM184090 US9150566, 128

InChI string: InChI=1S/C24H24FN7O2/c1-16-11-21(23(12-17(16)2)32-28-7-8-29-32)24(33)30-9-10-34-15-20(30)14-18-13-19(3-4-22(18)25)31-26-5-6-27-31/h3-8,11-13,20H,9-10,14-15H2,1-2H3/t20-/m1/s1

SMILES: Cc1cc(C(=O)N2CCOC[C@H]2Cc2cc(ccc2F)-n2nccn2)c(cc1C)-n1nccn1

InChI Key: InChIKey=DPAIDVFQHYLKSX-HXUWFJFHSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 184090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Orexin receptor 2


(Homo sapiens (Human))
BDBM184090
PNG
(US9150566, 128)
Show SMILES Cc1cc(C(=O)N2CCOC[C@H]2Cc2cc(ccc2F)-n2nccn2)c(cc1C)-n1nccn1
Show InChI InChI=1S/C24H24FN7O2/c1-16-11-21(23(12-17(16)2)32-28-7-8-29-32)24(33)30-9-10-34-15-20(30)14-18-13-19(3-4-22(18)25)31-26-5-6-27-31/h3-8,11-13,20H,9-10,14-15H2,1-2H3/t20-/m1/s1
PDB

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KEGG

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PC cid
PC sid
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Similars

AffyNet 
US Patent
n/an/a 30n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)

More data for this
Ligand-Target Pair
Orexin receptor 1


(Homo sapiens (Human))
BDBM184090
PNG
(US9150566, 128)
Show SMILES Cc1cc(C(=O)N2CCOC[C@H]2Cc2cc(ccc2F)-n2nccn2)c(cc1C)-n1nccn1
Show InChI InChI=1S/C24H24FN7O2/c1-16-11-21(23(12-17(16)2)32-28-7-8-29-32)24(33)30-9-10-34-15-20(30)14-18-13-19(3-4-22(18)25)31-26-5-6-27-31/h3-8,11-13,20H,9-10,14-15H2,1-2H3/t20-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.700n/an/an/an/an/an/a



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)

More data for this
Ligand-Target Pair