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BDBM184187 US9150577, 40

SMILES: CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2cc(C)ccc12

InChI Key: InChIKey=CEVWSVXHCJJEKH-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 184187   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase alpha 2


(Homo sapiens (human))
BDBM184187
PNG
(US9150577, 40)
Show SMILES CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2cc(C)ccc12
Show InChI InChI=1S/C23H23N5O2/c1-3-27-18-8-5-14(2)11-17(18)25-23(27)26-21(29)16-7-6-15-12-20-22(30)24-9-4-10-28(20)19(15)13-16/h5-8,11-13H,3-4,9-10H2,1-2H3,(H,24,30)(H,25,26,29)
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PC cid
PC sid
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Similars

US Patent
n/an/a 4.80n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9150577 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22V6
More data for this
Ligand-Target Pair