BDBM187213 US9670193, 4 N-benzyl-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)pyrimidin-2-amine (TFA-salt)

SMILES FC(F)(F)c1nc(no1)-c1cnc(NCc2ccccc2)nc1

InChI Key InChIKey=WKXDJTOUTKBAGX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 187213   

TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM187213(US9670193, 4 N-benzyl-5-(5-(trifluoromethyl)-1,2,4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Human recombinant full length HDAC1 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM187213(US9670193, 4 N-benzyl-5-(5-(trifluoromethyl)-1,2,4...)
Affinity DataIC50:  320nMAssay Description:Human recombinant full length HDAC6 expressed in a baculovirus expression system was purchased from BPS BioSciences (San Diego, Calif., U.S.A.). The ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4 [2-1084](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM187213(US9670193, 4 N-benzyl-5-(5-(trifluoromethyl)-1,2,4...)
Affinity DataIC50:  36nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent