BDBM18959 3-{[4-(2-aminoethoxy)-3,5-diiodophenyl]carbonyl}-2-butyl-1-benzofuran::CHEMBL1598::DDEA::Desdiethylamiodarone::Di-N-desethylamiodarone::L 33530::Methanone

SMILES CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN)c(I)c1

InChI Key InChIKey=ZOCLVGHDXBVATF-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 18959   

TargetThyroid hormone receptor alpha(Gallus gallus (chicken))
University Of Amsterdam

LigandPNGBDBM18959(3-{[4-(2-aminoethoxy)-3,5-diiodophenyl]carbonyl}-2...)
Affinity DataIC50:  3.70E+4nMpH: 7.6 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
University Of Amsterdam

LigandPNGBDBM18959(3-{[4-(2-aminoethoxy)-3,5-diiodophenyl]carbonyl}-2...)
Affinity DataIC50:  1.90E+4nMpH: 7.6 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM18959(3-{[4-(2-aminoethoxy)-3,5-diiodophenyl]carbonyl}-2...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at rat TAAR1 expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM18959(3-{[4-(2-aminoethoxy)-3,5-diiodophenyl]carbonyl}-2...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of recombinant HQ5-Halo-tagged KDM4A tudor domain (unknown origin) measured by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM18959(3-{[4-(2-aminoethoxy)-3,5-diiodophenyl]carbonyl}-2...)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of recombinant GST-tagged KDM4A double tudor domain (895 to 1011 residues) (unknown origin) using biotin-H3K4me3 ( 1 to 14 residues) pepti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of growth protein 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM18959(3-{[4-(2-aminoethoxy)-3,5-diiodophenyl]carbonyl}-2...)
Affinity DataIC50:  9.70E+4nMAssay Description:Inhibition of recombinant GST-tagged ING2 PHD (201 to 281 residues) (unknown origin) using biotin-H3K4me3 ( 1 to 14 residues) peptide substrate by fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM18959(3-{[4-(2-aminoethoxy)-3,5-diiodophenyl]carbonyl}-2...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of recombinant HQ5-Halo-tagged KDM5A PHD3 domain (unknown origin) measured by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM18959(3-{[4-(2-aminoethoxy)-3,5-diiodophenyl]carbonyl}-2...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of recombinant GST-tagged KDM5A PHD3 (1601 to 1660 residues) (unknown origin) using biotin-H3K4me3 ( 1 to 14 residues) peptide substrate b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed