BDBM190561 US9181185, 19::US9624194, Compound 19
SMILES NC(=O)[C@H](O)[C@@H](O)c1cccc(n1)-c1ccc(Oc2ccc(c(c2)C#N)C(F)(F)F)cc1
InChI Key InChIKey=OHLPNPPUDGBLLM-VQTJNVASSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 190561
Affinity DataKi: 347nM ΔG°: -9.16kcal/moleT: 2°CAssay Description:Cells: The hNav1.7 expressing HEK-293 cells were plated on 35 mm culture
dishes pre-coated with poly-D-lysine in standard DMEM culture media
(Media...More data for this Ligand-Target Pair
Affinity DataKi: 347nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.26E+3nMAssay Description:For electrophysiological recordings the external solution was either standard, DMEM supplemented with 10 mM HEPES (pH adjusted to 7.34 with NaOH and ...More data for this Ligand-Target Pair
Affinity DataIC50: 244nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by FLIPR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 244nMT: 2°CAssay Description:FLIPRŽ or FLIPRTETRAŽ Sodium Dye Assay with KCl and Test Article Pre-Incubation: Cells were prepared by plating the recombinant HEK293 cells or other...More data for this Ligand-Target Pair
Affinity DataIC50: 244nMAssay Description:Recombinant Nav1.7 Cell Line: In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN...More data for this Ligand-Target Pair