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BDBM190931 US10077266, Example 42::US9181249, 42::US9708313, 42

SMILES: CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F

InChI Key: InChIKey=JTNXLHFGSOWSSM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 190931   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190931
PNG
(US10077266, Example 42 | US9181249, 42 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-21(30-11-18(26)27)22(32-19)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,31)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.193n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190931
PNG
(US10077266, Example 42 | US9181249, 42 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-21(30-11-18(26)27)22(32-19)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,31)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.93E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190931
PNG
(US10077266, Example 42 | US9181249, 42 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-21(30-11-18(26)27)22(32-19)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,31)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 1.93E+5n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


Article DOI: 10.1021/jm061214f
More data for this
Ligand-Target Pair