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BDBM190997 US10077266, Example 110::US9181249, 110::US9708313, 110

SMILES: CC1Cc2nc(NCC(F)F)c(nc2CN1C(=O)C(F)F)N1CCC(CC1)Oc1ccc(F)cc1F

InChI Key: InChIKey=WREVJMIEEVIOQY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 190997   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190997
PNG
(US10077266, Example 110 | US9181249, 110 | US97083...)
Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1C(=O)C(F)F)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-8-16-17(11-34(12)23(35)20(28)29)32-22(21(31-16)30-10-19(26)27)33-6-4-14(5-7-33)36-18-3-2-13(24)9-15(18)25/h2-3,9,12,14,19-20H,4-8,10-11H2,1H3,(H,30,31)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 0.0221n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190997
PNG
(US10077266, Example 110 | US9181249, 110 | US97083...)
Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1C(=O)C(F)F)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-8-16-17(11-34(12)23(35)20(28)29)32-22(21(31-16)30-10-19(26)27)33-6-4-14(5-7-33)36-18-3-2-13(24)9-15(18)25/h2-3,9,12,14,19-20H,4-8,10-11H2,1H3,(H,30,31)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 2.21E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190997
PNG
(US10077266, Example 110 | US9181249, 110 | US97083...)
Show SMILES CC1Cc2nc(NCC(F)F)c(nc2CN1C(=O)C(F)F)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-8-16-17(11-34(12)23(35)20(28)29)32-22(21(31-16)30-10-19(26)27)33-6-4-14(5-7-33)36-18-3-2-13(24)9-15(18)25/h2-3,9,12,14,19-20H,4-8,10-11H2,1H3,(H,30,31)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 2.21E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair