BDBM191605 US9181263, 14::US9278100, 14

SMILES Nc1ncnc2n(C[C@@H]3CCCN3C(=O)C=C)nc(-c3ccc(Oc4ccccc4)cc3)c12

InChI Key InChIKey=MWNASUNUUFWMNK-SFHVURJKSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 191605   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM191605(US9181263, 14 | US9278100, 14)
Affinity DataIC50:  0.390nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM191605(US9181263, 14 | US9278100, 14)
Affinity DataIC50:  592nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM191605(US9181263, 14 | US9278100, 14)
Affinity DataIC50:  2.30nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM191605(US9181263, 14 | US9278100, 14)
Affinity DataIC50:  9.24nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM191605(US9181263, 14 | US9278100, 14)
Affinity DataIC50:  1.46E+3nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM191605(US9181263, 14 | US9278100, 14)
Affinity DataIC50:  0.390nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM191605(US9181263, 14 | US9278100, 14)
Affinity DataIC50:  592nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM191605(US9181263, 14 | US9278100, 14)
Affinity DataIC50:  2.30nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM191605(US9181263, 14 | US9278100, 14)
Affinity DataIC50:  9.24nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM191605(US9181263, 14 | US9278100, 14)
Affinity DataIC50:  1.46E+3nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails US Patent