BDBM191770 US10669227, Compound 7::US11608309, Compound 7::US9187406, Compound 7

SMILES Oc1ccc(\C=C\C(=O)C(C(=O)Nc2ccccc2)C(=O)\C=C\c2ccc(O)cc2)cc1

InChI Key InChIKey=ZPZMHBPRQOJARQ-OTYYAQKOSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 191770   

Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation Of State University Of New York

US Patent
LigandPNGBDBM191770(US10669227, Compound 7 | US11608309, Compound 7 | ...)
Affinity DataIC50:  1.25E+5nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
The Research Foundation Of State University Of New York

US Patent
LigandPNGBDBM191770(US10669227, Compound 7 | US11608309, Compound 7 | ...)
Affinity DataIC50: <1.00E+3nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
The Research Foundation Of State University Of New York

US Patent
LigandPNGBDBM191770(US10669227, Compound 7 | US11608309, Compound 7 | ...)
Affinity DataIC50: <1.00E+3nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
The Research Foundation Of State University Of New York

US Patent
LigandPNGBDBM191770(US10669227, Compound 7 | US11608309, Compound 7 | ...)
Affinity DataIC50: <1.00E+3nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation Of State University Of New York

US Patent
LigandPNGBDBM191770(US10669227, Compound 7 | US11608309, Compound 7 | ...)
Affinity DataIC50:  1.25E+5nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation Of State University Of New York

US Patent
LigandPNGBDBM191770(US10669227, Compound 7 | US11608309, Compound 7 | ...)
Affinity DataIC50:  1.25E+5nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent