BDBM19265 C2-Mycophenolic Adenine Dinucleotide (C2-MDA)::CHEMBL410744::[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)methyl][2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]phosphinic acid

SMILES COc1c(C)c2COC(=O)c2c(O)c1CCOP(O)(=O)CP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12

InChI Key InChIKey=AMYUZLUBFKOUEX-JKWAKEATSA-N

Data  8 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 19265   

TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM19265(C2-Mycophenolic Adenine Dinucleotide (C2-MDA) | CH...)
Affinity DataKi:  250nMAssay Description:Inhibition of IMPDH2 (unknown origin)More data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM19265(C2-Mycophenolic Adenine Dinucleotide (C2-MDA) | CH...)
Affinity DataKi:  250nMAssay Description:Inhibition of human IMPDH2 by SpectrophotometerMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM19265(C2-Mycophenolic Adenine Dinucleotide (C2-MDA) | CH...)
Affinity DataKi:  250nMAssay Description:Inhibition of human IMP dehydrogenase 2More data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM19265(C2-Mycophenolic Adenine Dinucleotide (C2-MDA) | CH...)
Affinity DataKi:  250nM ΔG°:  -9.00kcal/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 2 (33 and 66 nM) and varying concentrations of i...More data for this Ligand-Target Pair
TargetLanosterol synthase(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM19265(C2-Mycophenolic Adenine Dinucleotide (C2-MDA) | CH...)
Affinity DataKi:  300nMAssay Description:Inhibition of IMPDH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM19265(C2-Mycophenolic Adenine Dinucleotide (C2-MDA) | CH...)
Affinity DataKi:  330nMAssay Description:Inhibition of human IMPDH1 by SpectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM19265(C2-Mycophenolic Adenine Dinucleotide (C2-MDA) | CH...)
Affinity DataKi:  330nM ΔG°:  -8.84kcal/molepH: 8.0 T: 2°CAssay Description:Inhibition assays were performed in duplicate using two different concentrations of human IMPDH type 1 (87 and 155 nM) and varying concentrations of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM19265(C2-Mycophenolic Adenine Dinucleotide (C2-MDA) | CH...)
Affinity DataKi:  330nMAssay Description:Inhibition of human IMP dehydrogenase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed