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BDBM192715 YKL-05-096 (4)

InChI string: InChI=1S/C31H33ClN8O3/c1-20-6-5-7-24(32)28(20)39-19-21-17-34-30(36-29(21)40(31(39)41)27-11-9-23(42-3)18-33-27)35-25-10-8-22(16-26(25)43-4)38-14-12-37(2)13-15-38/h5-11,16-18H,12-15,19H2,1-4H3,(H,34,35,36)

SMILES: COc1ccc(nc1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc12)c1c(C)cccc1Cl

InChI Key: InChIKey=JPYJYNNIQRTRFF-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 192715   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-10 (IL-10)


(Homo sapiens (Human))
BDBM192715
PNG
(YKL-05-096 (4))
Show SMILES COc1ccc(nc1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc12)c1c(C)cccc1Cl
Show InChI InChI=1S/C31H33ClN8O3/c1-20-6-5-7-24(32)28(20)39-19-21-17-34-30(36-29(21)40(31(39)41)27-11-9-23(42-3)18-33-27)35-25-10-8-22(16-26(25)43-4)38-14-12-37(2)13-15-38/h5-11,16-18H,12-15,19H2,1-4H3,(H,34,35,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 70n/an/an/an/a



Broad Institute



Assay Description
Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...


ACS Chem Biol 11: 2105-11 (2016)

More data for this
Ligand-Target Pair
Salt-inducible kinase 2 (SIK2)


(Homo sapiens (Human))
BDBM192715
PNG
(YKL-05-096 (4))
Show SMILES COc1ccc(nc1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc12)c1c(C)cccc1Cl
Show InChI InChI=1S/C31H33ClN8O3/c1-20-6-5-7-24(32)28(20)39-19-21-17-34-30(36-29(21)40(31(39)41)27-11-9-23(42-3)18-33-27)35-25-10-8-22(16-26(25)43-4)38-14-12-37(2)13-15-38/h5-11,16-18H,12-15,19H2,1-4H3,(H,34,35,36)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Broad Institute



Assay Description
IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...


ACS Chem Biol 11: 2105-11 (2016)

More data for this
Ligand-Target Pair