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BDBM193389 US9670208, Example 111

SMILES: CCOCCc1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1

InChI Key: InChIKey=CIXWCNQXLCUFIJ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193389   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase ERK2


(Homo sapiens (human))
BDBM193389
PNG
(US9670208, Example 111)
Show SMILES CCOCCc1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1
Show InChI InChI=1S/C18H20N8O/c1-3-27-11-7-16-23-24-17-12-13(6-10-26(16)17)14-4-8-19-18(21-14)22-15-5-9-20-25(15)2/h4-6,8-10,12H,3,7,11H2,1-2H3,(H,19,21,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.90n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair