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BDBM193757 US9670208, Example 377 4-(3-((dimethylamino)(4-fluorophenyl)methyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-(1-methyl-1H-pyrazol-5-yl)pyrimidin-2-amine

SMILES: CN(C)C(c1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1)c1ccc(F)cc1

InChI Key: InChIKey=BXRXTKQHAKJPPN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193757   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase ERK2


(Homo sapiens (human))
BDBM193757
PNG
(US9670208, Example 377 4-(3-((dimethylamino)(4-flu...)
Show SMILES CN(C)C(c1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1)c1ccc(F)cc1
Show InChI InChI=1S/C23H22FN9/c1-31(2)21(15-4-6-17(24)7-5-15)22-30-29-20-14-16(10-13-33(20)22)18-8-11-25-23(27-18)28-19-9-12-26-32(19)3/h4-14,21H,1-3H3,(H,25,27,28)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 5.40n/an/an/an/an/an/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair