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BDBM193892 4-(4-Chlorobenzyl)-6-(3,5-dimethylisoxazol-4-yl)-3,4-dihydroquinoxalin-2(1H)-one (5k)

SMILES: Cc1noc(C)c1-c1ccc2NC(=O)CN(Cc3ccc(Cl)cc3)c2c1

InChI Key: InChIKey=NRXRQTLJYNSLMD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193892   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4 (BRD4)


(Homo sapiens (Human))
BDBM193892
PNG
(4-(4-Chlorobenzyl)-6-(3,5-dimethylisoxazol-4-yl)-3...)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)CN(Cc3ccc(Cl)cc3)c2c1
Show InChI InChI=1S/C20H18ClN3O2/c1-12-20(13(2)26-23-12)15-5-8-17-18(9-15)24(11-19(25)22-17)10-14-3-6-16(21)7-4-14/h3-9H,10-11H2,1-2H3,(H,22,25)
PDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 500n/an/an/an/an/a25



China Pharmaceutical University



Assay Description
11 compounds were evaluated against BRD4-BD1 in vitro with compound 28a as the reference compound. BRD4 (44-168 aa) was bought from Active Motif. Aft...


Bioorg Chem 68: 236-44 (2016)


Article DOI: 10.1016/j.bioorg.2016.08.009
BindingDB Entry DOI: 10.7270/Q2VM4B24
More data for this
Ligand-Target Pair